Issue 3, 2015

Effects of rosmarinic acid on liver and kidney antioxidant enzymes, lipid peroxidation and tissue ultrastructure in aging mice

Abstract

Rosmarinic acid (RA), which is a natural polyphenol, was isolated from Rosmarinus. officinalis L. The aim of this study is to evaluate the effects of rosmarinic acid on liver and kidney antioxidant enzymes and the tissue ultrastructure in aging mice. RA was administrated at a dosage of 50, 100 or 200 mg kgāˆ’1 once a day with a normal control group and an aging control group for 30 days. The livers and kidneys of the mice were harvested for antioxidant enzyme activities and histological assessments. RA produced significant (p < 0.05 or p < 0.01) increases in the activity of superoxide dismutase (SOD) catalase (CAT) and glutathione peroxidase (GSH-Px) with a decrease in malondialdehyde (MDA) at 200 mg kgāˆ’1 compared to the aging control. The histopathological study showed RA may induce significant structural changes in liver and kidney tissues at 200 mg kgāˆ’1. The results in this study demonstrate that RA has the potential for promoting in vivo antioxidant enzyme activity.

Graphical abstract: Effects of rosmarinic acid on liver and kidney antioxidant enzymes, lipid peroxidation and tissue ultrastructure in aging mice

Article information

Article type
Paper
Submitted
18 Nov 2014
Accepted
05 Jan 2015
First published
07 Jan 2015

Food Funct., 2015,6, 927-931

Author version available

Effects of rosmarinic acid on liver and kidney antioxidant enzymes, lipid peroxidation and tissue ultrastructure in aging mice

Y. Zhang, X. Chen, L. Yang, Y. Zu and Q. Lu, Food Funct., 2015, 6, 927 DOI: 10.1039/C4FO01051E

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