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Issue 11, 2015
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Characterisation and application of ultra-high spin clusters as magnetic resonance relaxation agents

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Abstract

In Magnetic Resonance Tomography (MRT) image contrast can be improved by adding paramagnetic relaxation agents such as lanthanide ions. Here we report on the use of highly paramagnetic isostructural FeIII/4f coordination clusters with a [Fe10Ln10] core to enhance relaxation. Measurements were performed over the range of 1H Larmor frequencies of 10 MHz to 1.4 GHz in order to determine the relevant parameters for longitudinal and transverse relaxivities. Variation of the lanthanide ion allows differentiation of relaxation contributions from electronic states and molecular dynamics. We find that the transverse relaxivities increase with field, whereas the longitudinal relaxivities depend on the nature of the lanthanide. In addition, the GdIII analogue was selected in particular to test the interaction with tissue observed using MRT. Studies on biofilms used in waste water treatment reveal that the behaviour of the high-spin clusters is different from what is observed for common relaxation agents with respect to the penetration into the biofilms. The Fe10Gd10 cluster adheres to the surface of the biofilm better than the commercial agent Gadovist.

Graphical abstract: Characterisation and application of ultra-high spin clusters as magnetic resonance relaxation agents

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Publication details

The article was received on 23 Sep 2014, accepted on 03 Feb 2015 and first published on 11 Feb 2015


Article type: Paper
DOI: 10.1039/C4DT02916J
Citation: Dalton Trans., 2015,44, 5032-5040
  • Open access: Creative Commons BY license
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    Characterisation and application of ultra-high spin clusters as magnetic resonance relaxation agents

    G. Guthausen, J. R. Machado, B. Luy, A. Baniodeh, A. K. Powell, S. Krämer, F. Ranzinger, M. P. Herrling, S. Lackner and H. Horn, Dalton Trans., 2015, 44, 5032
    DOI: 10.1039/C4DT02916J

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