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Issue 11, 2015
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EuroTracker® dyes: design, synthesis, structure and photophysical properties of very bright europium complexes and their use in bioassays and cellular optical imaging

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Abstract

The development of the brightest luminescent europium(III) complexes is traced, including analysis of the C3-symmetric core complex based on a functionalized triazacyclononane and identification of the most suitable strongly absorbing chromophore. Strategies for the synthesis of the complexes, including enantiopure analogues, are outlined and opportunities for applications in time-resolved microscopy and spectral imaging emphasised. Practicable examples are introduced, including selective organelle staining for cellular optical imaging at 65 nm resolution and the development of new bioassays using time-resolved FRET methods.

Graphical abstract: EuroTracker® dyes: design, synthesis, structure and photophysical properties of very bright europium complexes and their use in bioassays and cellular optical imaging

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Publication details

The article was received on 11 Sep 2014, accepted on 10 Oct 2014 and first published on 13 Oct 2014


Article type: Perspective
DOI: 10.1039/C4DT02785J
Author version available: Download Author version (PDF)
Citation: Dalton Trans., 2015,44, 4791-4803
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    EuroTracker® dyes: design, synthesis, structure and photophysical properties of very bright europium complexes and their use in bioassays and cellular optical imaging

    S. J. Butler, M. Delbianco, L. Lamarque, B. K. McMahon, E. R. Neil, R. Pal, D. Parker, J. W. Walton and J. M. Zwier, Dalton Trans., 2015, 44, 4791
    DOI: 10.1039/C4DT02785J

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