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Issue 3, 2015
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Deracemisation of profenol core by combining laccase/TEMPO-mediated oxidation and alcohol dehydrogenase-catalysed dynamic kinetic resolution

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Abstract

A mild one-pot methodology has been developed to deracemise rac-2-phenyl-1-propanol by combining the use of non-selective laccase/TEMPO-mediated oxidation with enantioselective bioreduction of the racemic aldehyde intermediate under dynamic conditions. The process was easily scalable and stereocontrollable by selecting the suitable biocatalyst.

Graphical abstract: Deracemisation of profenol core by combining laccase/TEMPO-mediated oxidation and alcohol dehydrogenase-catalysed dynamic kinetic resolution

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Publication details

The article was received on 15 Oct 2014, accepted on 21 Jan 2015 and first published on 22 Jan 2015


Article type: Communication
DOI: 10.1039/C4CY01351D
Citation: Catal. Sci. Technol., 2015,5, 1443-1446
  • Open access: Creative Commons BY license
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    Deracemisation of profenol core by combining laccase/TEMPO-mediated oxidation and alcohol dehydrogenase-catalysed dynamic kinetic resolution

    A. Díaz-Rodríguez, N. Ríos-Lombardía, J. H. Sattler, I. Lavandera, V. Gotor-Fernández, W. Kroutil and V. Gotor, Catal. Sci. Technol., 2015, 5, 1443
    DOI: 10.1039/C4CY01351D

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