Issue 12, 2015

Dendritic glycopolymers based on dendritic polyamine scaffolds: view on their synthetic approaches, characteristics and potential for biomedical applications

Abstract

In this review we highlight the potential for biomedical applications of dendritic glycopolymers based on polyamine scaffolds. The complex interplay of the molecular characteristics of the dendritic architectures and their specific interactions with various (bio)molecules are elucidated with various examples. A special role of the individual sugar units attached to the dendritic scaffolds and their density is identified, which govern ionic and H-bond interactions, and biological targeting, but to a large extent are also responsible for the significantly reduced toxicity of the dendritic glycopolymers compared to their polyamine scaffolds. Thus, the application of dendritic glycopolymers in drug delivery systems for gene transfection but also as therapeutics in neurodegenerative diseases has great promise.

Graphical abstract: Dendritic glycopolymers based on dendritic polyamine scaffolds: view on their synthetic approaches, characteristics and potential for biomedical applications

Article information

Article type
Review Article
Submitted
14 Oct 2014
First published
18 Dec 2014
This article is Open Access
Creative Commons BY-NC license

Chem. Soc. Rev., 2015,44, 3968-3996

Author version available

Dendritic glycopolymers based on dendritic polyamine scaffolds: view on their synthetic approaches, characteristics and potential for biomedical applications

D. Appelhans, B. Klajnert-Maculewicz, A. Janaszewska, J. Lazniewska and B. Voit, Chem. Soc. Rev., 2015, 44, 3968 DOI: 10.1039/C4CS00339J

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