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Issue 3, 2015
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Integrative self-sorting: a versatile strategy for the construction of complex supramolecular architecture

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Abstract

Large protein-sized synthetic supramolecular architecture is rare and certainly has not yet achieved the structural and functional complexity of biomolecules. As multiple, identical copies of a few building blocks are repetitively used, a highly symmetrical architecture results with limitations in function. In marked contrast, functional structures in nature are often assembled with high geometric precision from many different building blocks. They cooperate in a complex way realizing energy conversion, mechanical motion or transport phenomena. Beyond self-assembly, the structurally and functionally complex biomolecular machines rely on self-sorting to correctly position all subunits through orthogonal recognition sites. Mimicking such self-sorting processes is a promising strategy for supramolecular synthesis – resulting in higher structural complexity and promising access to a more sophisticated function. The term “integrative self-sorting” was coined to describe the strategy to form well-defined assemblies with well-controlled subunit positions. The key process is the incorporation of two or more orthogonal binding motifs into at least some of the subunits. Modularity and programmability based on orthogonal yet similar binding motifs generate diversity and complexity. Integrative self-sorting is thus inherently related to systems chemistry. Depending on the individual binding motifs, (multi-)stimuli responsiveness can be achieved. When different recognition events en route to the final assembly occur on significantly different time scales, kinetic pathway selection is observed. In this account, we review the modularity, programmability, and emergent properties of integrative self-sorting, emphasizing its utility and perspective for complex supramolecular architectures.

Graphical abstract: Integrative self-sorting: a versatile strategy for the construction of complex supramolecular architecture

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Publication details

The article was received on 15 Sep 2014 and first published on 06 Nov 2014


Article type: Review Article
DOI: 10.1039/C4CS00305E
Citation: Chem. Soc. Rev., 2015,44, 779-789
  • Open access: Creative Commons BY-NC license
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    Integrative self-sorting: a versatile strategy for the construction of complex supramolecular architecture

    Z. He, W. Jiang and C. A. Schalley, Chem. Soc. Rev., 2015, 44, 779
    DOI: 10.1039/C4CS00305E

    This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence. Material from this article can be used in other publications provided that the correct acknowledgement is given with the reproduced material and it is not used for commercial purposes.

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