Issue 47, 2015
From the journal:

CrystEngComm

Direct co-crystal assembly from synthesis to co-crystallization†

Hung Lin Leea  and  Tu Lee*a  

* Corresponding authors

a Department of Chemical and Materials Engineering, National Central University, 300 Jhong-Da Road, Jhong-Li City 320, Taiwan, ROC
E-mail: tulee@cc.ncu.edu.tw

Abstract

Pharmaceutical co-crystals were assembled directly via chemical synthesis by cooling under three new strategies. The screening method for direct co-crystal assembly by a chemical reaction was developed based on liquid-assisted grinding. The ternary phase diagram including a chemical reaction and co-crystallization was established for a 2 : 1 co-crystal of benzoic acid–sodium benzoate.

Graphical abstract: Direct co-crystal assembly from synthesis to co-crystallization

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Article information

DOI
https://doi.org/10.1039/C5CE01205H
Article type
Communication
Submitted
22 Jun 2015
Accepted
14 Aug 2015
First published
14 Aug 2015

CrystEngComm, 2015,17, 9002-9006

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Direct co-crystal assembly from synthesis to co-crystallization

H. L. Lee and T. Lee, CrystEngComm, 2015, 17, 9002 DOI: 10.1039/C5CE01205H

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