Jump to main content
Jump to site search

Issue 27, 2015
Previous Article Next Article

Chiral discrimination by a cellulose polymer: differential crystallization inhibition of enantiomers in amorphous dispersions

Author affiliations

Abstract

With the goal of better understanding how polymers inhibit crystallization in amorphous solid dispersions, crystal growth rates of the R and S enantiomers of a model chiral compound in the presence of chiral and achiral polymers were evaluated. The crystal growth rates of enantiomers in undercooled melts were inhibited to different extents by the same mass fraction of a chiral polymer, hydroxypropylmethyl cellulose acetate succinate. This is most likely due to differences in the ability of each enantiomer to form hydrogen bonding interactions with the polymer, which in turn impacts the crystallization behavior of the low molecular weight organic compound. In contrast, the achiral polymer polyvinylpyrrolidone, and the chiral polymer, hydroxypropylmethylcellulose phthalate showed the same inhibitory impact on each enantiomer.

Graphical abstract: Chiral discrimination by a cellulose polymer: differential crystallization inhibition of enantiomers in amorphous dispersions

Back to tab navigation

Supplementary files

Publication details

The article was received on 25 Apr 2015, accepted on 09 Jun 2015 and first published on 10 Jun 2015


Article type: Paper
DOI: 10.1039/C5CE00810G
Citation: CrystEngComm, 2015,17, 5046-5053
  •   Request permissions

    Chiral discrimination by a cellulose polymer: differential crystallization inhibition of enantiomers in amorphous dispersions

    T. Sato and L. S. Taylor, CrystEngComm, 2015, 17, 5046
    DOI: 10.1039/C5CE00810G

Search articles by author

Spotlight

Advertisements