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Issue 93, 2015
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Efficient singlet oxygen generation from sugar pendant C60 derivatives for photodynamic therapy

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Abstract

The amidation reaction between C60 with an activated ester group (1) and acetylated Glc (AcGlc) with an amino group (2) was performed to yield the target AcGlc-pendant C60 compound (3). The water soluble deacetylated compound, Glc-pendant C60 compound (4), exhibited high photocytotoxicity against HeLa cells due to the more efficient singlet oxygen generation as compared with that of Glc-pendant azafulleroids.

Graphical abstract: Efficient singlet oxygen generation from sugar pendant C60 derivatives for photodynamic therapy

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Publication details

The article was received on 02 Sep 2015, accepted on 17 Sep 2015 and first published on 17 Sep 2015


Article type: Communication
DOI: 10.1039/C5CC07353G
Citation: Chem. Commun., 2015,51, 16605-16608
  • Open access: Creative Commons BY-NC license
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    Efficient singlet oxygen generation from sugar pendant C60 derivatives for photodynamic therapy

    S. Yano, M. Naemura, A. Toshimitsu, M. Akiyama, A. Ikeda, J. Kikuchi, X. Shen, Q. Duan, A. Narumi, M. Inoue, K. Ohkubo and S. Fukuzumi, Chem. Commun., 2015, 51, 16605
    DOI: 10.1039/C5CC07353G

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      [Original citation] - Published by The Royal Society of Chemistry.

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