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Issue 97, 2015
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Surface vs. solution hybridization: effects of salt, temperature, and probe type

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Abstract

Hybridization thermodynamics on solid supports are compared with those in solution for two types of hybridization probe, DNA and uncharged morpholino oligonucleotides of identical sequences. Trends in hybridization affinity are discussed with respect to ionic strength, temperature, and surface behavior.

Graphical abstract: Surface vs. solution hybridization: effects of salt, temperature, and probe type

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Publication details

The article was received on 09 Aug 2015, accepted on 01 Oct 2015 and first published on 01 Oct 2015


Article type: Communication
DOI: 10.1039/C5CC06674C
Citation: Chem. Commun., 2015,51, 17245-17248
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    Surface vs. solution hybridization: effects of salt, temperature, and probe type

    W. Qiao, H. Chiang, H. Xie and R. Levicky, Chem. Commun., 2015, 51, 17245
    DOI: 10.1039/C5CC06674C

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