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Issue 87, 2015
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Direct gem-difluoromethylenation of sp3-hybridized carbon center through copper-mediated radical/radical cross-coupling for the construction of a CH2–CF2 linkage

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Abstract

Efficient direct gem-difluoromethylenation of an sp3-hybridized carbon center in benzyl bromides using benzo-1,3-azolic (oxa-, thia- or aza-) difluoromethyl bromides for construction of a CH2–CF2 linkage has been developed through radical/radical C–C cross-coupling via two separate single electron transfer processes (SET) under the promotion of different copper sources.

Graphical abstract: Direct gem-difluoromethylenation of sp3-hybridized carbon center through copper-mediated radical/radical cross-coupling for the construction of a CH2–CF2 linkage

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Publication details

The article was received on 09 Jul 2015, accepted on 10 Aug 2015 and first published on 27 Aug 2015


Article type: Communication
DOI: 10.1039/C5CC05677B
Citation: Chem. Commun., 2015,51, 15756-15759
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    Direct gem-difluoromethylenation of sp3-hybridized carbon center through copper-mediated radical/radical cross-coupling for the construction of a CH2–CF2 linkage

    H. Jiang, M. Xu, W. Lu, W. Tian, W. Wan, Y. Chen, H. Deng, S. Wu and J. Hao, Chem. Commun., 2015, 51, 15756
    DOI: 10.1039/C5CC05677B

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