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Issue 74, 2015
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Reversible DNA i-motif to hairpin switching induced by copper(II) cations

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Abstract

i-Motif DNA structures have previously been utilised for many different nanotechnological applications, but all have used changes in pH to fold the DNA. Herein we describe how copper(II) cations can alter the conformation of i-motif DNA into an alternative hairpin structure which is reversible by chelation with EDTA.

Graphical abstract: Reversible DNA i-motif to hairpin switching induced by copper(ii) cations

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Publication details

The article was received on 22 Jun 2015, accepted on 03 Aug 2015 and first published on 03 Aug 2015


Article type: Communication
DOI: 10.1039/C5CC05111H
Citation: Chem. Commun., 2015,51, 14099-14102
  • Open access: Creative Commons BY license
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    Reversible DNA i-motif to hairpin switching induced by copper(II) cations

    H. A. Day, E. P. Wright, C. J. MacDonald, A. J. Gates and Z. A. E. Waller, Chem. Commun., 2015, 51, 14099
    DOI: 10.1039/C5CC05111H

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