Issue 75, 2015

Functionalized ultrathin palladium nanosheets as patches for HepG2 cancer cells

Abstract

Flexible, charged Pd nanosheets were prepared by using short chain thiolated carboxylic acids and amines. They could wrap around amine or hydroxyl functionalized micron-sized spheres driven by electrostatic interactions. Upon incubation with HepG2 cells, the positively charged cysteamine (CA) functionalized Pd nanosheets exhibited a much higher cytotoxicity, showing more than 80% cell death at 100 ppm than the negatively charged 3-mercaptopropionic acid (MPA) functionalized ones which caused 30% cell death. The results show through surface functionalization Pd nanosheets can be modified to interact differently with HepG2 cancerous cells, resulting in varied cytotoxicity.

Graphical abstract: Functionalized ultrathin palladium nanosheets as patches for HepG2 cancer cells

Supplementary files

Article information

Article type
Communication
Submitted
08 Jun 2015
Accepted
31 Jul 2015
First published
31 Jul 2015

Chem. Commun., 2015,51, 14171-14174

Author version available

Functionalized ultrathin palladium nanosheets as patches for HepG2 cancer cells

Y. Pan, C. E. Smith, K. S. Kwok, J. Chen, H. Kong and H. Yang, Chem. Commun., 2015, 51, 14171 DOI: 10.1039/C5CC04727G

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