Issue 76, 2015
From the journal:

Chemical Communications

Two site genetic incorporation of varying length polyethylene glycol into the backbone of one peptide†

Qingmin Zang,‡ab   Seiichi Tada,‡a   Takanori Uzawa,ac   Daisuke Kiga,ab   Masayuki Yamamuraab  and  Yoshihiro Ito*abc  

* Corresponding authors

a Nano Medical Engineering Laboratory, RIKEN, 2-1 Hirosawa, Wako, Saitama 351-0198, Japan
E-mail: y-ito@riken.jp

b Department of Computational Intelligence and Systems Science, Interdisciplinary Graduate School of Science and Engineering, Tokyo Institute of Technology, 4259 Nagatsuta-cho, Midori-ku, Yokohama, Kanagawa 226-8501, Japan

c Emergent Bioengineering Materials Research Team, RIKEN Center for Emergent Matter Science, 2-1 Hirosawa, Wako, Saitama 351-0198, Japan

Abstract

Polyethylene glycol (PEG) of different lengths was genetically incorporated into the backbone of a polypeptide using stop-anticodon and frameshift anticodon-containing tRNAs, which were acylated with PEG-containing amino acids.

Graphical abstract: Two site genetic incorporation of varying length polyethylene glycol into the backbone of one peptide

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Article information

DOI
https://doi.org/10.1039/C5CC04486C
Article type
Communication
Submitted
04 Jun 2015
Accepted
31 Jul 2015
First published
31 Jul 2015

Chem. Commun., 2015,51, 14385-14388

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Two site genetic incorporation of varying length polyethylene glycol into the backbone of one peptide

Q. Zang, S. Tada, T. Uzawa, D. Kiga, M. Yamamura and Y. Ito, Chem. Commun., 2015, 51, 14385 DOI: 10.1039/C5CC04486C

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