Jump to main content
Jump to site search

Issue 53, 2015
Previous Article Next Article

Functional native disulfide bridging enables delivery of a potent, stable and targeted antibody–drug conjugate (ADC)

Author affiliations

Abstract

Herein we report the use of next generation maleimides (NGMs) for the construction of a potent antibody–drug conjugate (ADC) via functional disulfide bridging. The linker has excellent stability in blood serum and the ADC, armed with monomethyl auristatin E (MMAE), shows excellent potency and cancer cell selectivity in vitro.

Graphical abstract: Functional native disulfide bridging enables delivery of a potent, stable and targeted antibody–drug conjugate (ADC)

Back to tab navigation

Supplementary files

Publication details

The article was received on 28 Apr 2015, accepted on 29 May 2015 and first published on 01 Jun 2015


Article type: Communication
DOI: 10.1039/C5CC03557K
Citation: Chem. Commun., 2015,51, 10624-10627
  • Open access: Creative Commons BY license
  •   Request permissions

    Functional native disulfide bridging enables delivery of a potent, stable and targeted antibody–drug conjugate (ADC)

    J. P. M. Nunes, M. Morais, V. Vassileva, E. Robinson, V. S. Rajkumar, M. E. B. Smith, R. B. Pedley, S. Caddick, J. R. Baker and V. Chudasama, Chem. Commun., 2015, 51, 10624
    DOI: 10.1039/C5CC03557K

    This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. Material from this article can be used in other publications provided that the correct acknowledgement is given with the reproduced material.

    Reproduced material should be attributed as follows:

    • For reproduction of material from NJC:
      [Original citation] - Published by The Royal Society of Chemistry (RSC) on behalf of the Centre National de la Recherche Scientifique (CNRS) and the RSC.
    • For reproduction of material from PCCP:
      [Original citation] - Published by the PCCP Owner Societies.
    • For reproduction of material from PPS:
      [Original citation] - Published by The Royal Society of Chemistry (RSC) on behalf of the European Society for Photobiology, the European Photochemistry Association, and RSC.
    • For reproduction of material from all other RSC journals:
      [Original citation] - Published by The Royal Society of Chemistry.

    Information about reproducing material from RSC articles with different licences is available on our Permission Requests page.

Search articles by author

Spotlight

Advertisements