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Issue 46, 2015
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Catalytic amidation of unactivated ester derivatives mediated by trifluoroethanol

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Abstract

A catalytic amidation method has been developed, employing 2,2,2-trifluoroethanol to facilitate condensation of unactivated esters and amines, enabling the synthesis of a range of amide products in good to excellent yields. Mechanistic studies indicate the reaction proceeds through a trifluoroethanol-derived active ester intermediate.

Graphical abstract: Catalytic amidation of unactivated ester derivatives mediated by trifluoroethanol

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Publication details

The article was received on 08 Apr 2015, accepted on 08 May 2015 and first published on 08 May 2015


Article type: Communication
DOI: 10.1039/C5CC02895G
Author version available: Download Author version (PDF)
Citation: Chem. Commun., 2015,51, 9495-9498
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    Catalytic amidation of unactivated ester derivatives mediated by trifluoroethanol

    N. Caldwell, C. Jamieson, I. Simpson and A. J. B. Watson, Chem. Commun., 2015, 51, 9495
    DOI: 10.1039/C5CC02895G

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