A formal total synthesis of the cytotoxic natural product lactimidomycin has been achieved in nine steps from (E)-2-methyl-2-pentenoic acid. The 12-membered lactone was efficiently formed via a copper-catalyzed ene–yne coupling/alkyne reduction tandem reaction.
W. Li and G. I. Georg, Chem. Commun., 2015, 51, 8634 DOI: 10.1039/C5CC02571K
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