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Issue 45, 2015
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Synthesis of a heterogeneous artificial metallolipase with chimeric catalytic activity

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Abstract

A solid-phase strategy using lipase as a biomolecular scaffold to produce a large amount of Cu2+-metalloenzyme is proposed here. The application of this protocol on different 3D cavities of the enzyme allows creating a heterogeneous artificial metallolipase showing chimeric catalytic activity. The artificial catalyst was assessed in Diels–Alder cycloaddition reactions and cascade reactions showing excellent catalytic properties.

Graphical abstract: Synthesis of a heterogeneous artificial metallolipase with chimeric catalytic activity

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Publication details

The article was received on 24 Mar 2015, accepted on 27 Apr 2015 and first published on 27 Apr 2015


Article type: Communication
DOI: 10.1039/C5CC02450A
Citation: Chem. Commun., 2015,51, 9324-9327
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    Synthesis of a heterogeneous artificial metallolipase with chimeric catalytic activity

    M. Filice, O. Romero, J. Gutiérrez-Fernández, B. de las Rivas, J. A. Hermoso and J. M. Palomo, Chem. Commun., 2015, 51, 9324
    DOI: 10.1039/C5CC02450A

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