A highly efficient catalytic kinetic resolution of 2,3-epoxy 3-aryl ketones via asymmetric ring-opening with pyrazole derivatives has been achieved by using a chiral N,N′-dioxide–Sc(III) complex as the catalyst. A wide variety of substrates were readily scoped, and the selectivity factors obtained were excellent (up to >300).
T. Huang, L. Lin, X. Hu, J. Zheng, X. Liu and X. Feng, Chem. Commun., 2015, 51, 11374 DOI: 10.1039/C5CC02179K
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