A chiral cooperative catalysis of NHC and Brønsted acid for a formal [4+2] reaction of unprotected isatins and enals was developed for the direct synthesis of unprotected spiro[indoline-3,2′-pyran]-2,6′(3′H)-diones in good to excellent yields (up to 95%) with high enantioselectivities (up to >93% ee).
Y. Lin, L. Yang, Y. Deng and G. Zhong, Chem. Commun., 2015, 51, 8330 DOI: 10.1039/C5CC02096D
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