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Issue 41, 2015
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Lipopeptides: from self-assembly to bioactivity

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Abstract

This Feature Article discusses several classes of lipopeptide with important biomedical applications as antimicrobial and antifungal agents, in immune therapies and in personal care applications among others. Two main classes of lipopeptide are considered: (i) bacterially-expressed lipopeptides with a cyclic peptide headgroup and (ii) linear lipopeptides (with one or more lipid chains) based on bio-derived and bio-inspired amino acid sequences with current clinical applications. The applications are briefly summarized, and the biophysical characterization of the molecules is reviewed, with a particular focus on self-assembly. For several of these types of biomolecule, the formation of micelles above a critical micelle concentration has been observed while others form bilayer structures, depending on conditions of pH and temperature. As yet, there are few studies on the possible relationship between self-assembly into structures such as micelles and bioactivity of this class of molecule although this is likely to attract further attention.

Graphical abstract: Lipopeptides: from self-assembly to bioactivity

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Publication details

The article was received on 19 Feb 2015, accepted on 18 Mar 2015 and first published on 18 Mar 2015


Article type: Feature Article
DOI: 10.1039/C5CC01535A
Citation: Chem. Commun., 2015,51, 8574-8583
  • Open access: Creative Commons BY license
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    Lipopeptides: from self-assembly to bioactivity

    I. W. Hamley, Chem. Commun., 2015, 51, 8574
    DOI: 10.1039/C5CC01535A

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