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Issue 30, 2015
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Expanding the scope of strained-alkyne chemistry: a protection–deprotection strategy via the formation of a dicobalt–hexacarbonyl complex

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Abstract

A protection–deprotection strategy for strained alkynes used for bioorthogonal chemistry is reported. A strained alkyne can be protected with dicobalt–octacarbonyl and we demonstrate for the first time that a strained alkyne can be re-formed and isolated under mild reaction conditions for further bioorthogonal reactivity. The protection–deprotection strategy herein reported will expand the versatility of strained alkynes for the preparation of substrates in chemical biology and materials applications.

Graphical abstract: Expanding the scope of strained-alkyne chemistry: a protection–deprotection strategy via the formation of a dicobalt–hexacarbonyl complex

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Publication details

The article was received on 18 Feb 2015, accepted on 12 Mar 2015 and first published on 12 Mar 2015


Article type: Communication
DOI: 10.1039/C5CC01522G
Author version available: Download Author version (PDF)
Citation: Chem. Commun., 2015,51, 6647-6650
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    Expanding the scope of strained-alkyne chemistry: a protection–deprotection strategy via the formation of a dicobalt–hexacarbonyl complex

    P. Gobbo, T. Romagnoli, S. M. Barbon, J. T. Price, J. Keir, J. B. Gilroy and M. S. Workentin, Chem. Commun., 2015, 51, 6647
    DOI: 10.1039/C5CC01522G

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