SCHEDULED MAINTENANCE
Two second-generation quadruplex hammerhead ribozymes, whose activity enhances in response to K+via quadruplex formation of embedded r(GGA)3GG, were developed. Different strategies were applied to suppress basal activity when K+ is absent. As a result, the activity enhancement upon the addition of K+ has reached as high as 21-fold.
Y. Yamaoki, T. Mashima, T. Nagata and M. Katahira, Chem. Commun., 2015, 51, 5898 DOI: 10.1039/C5CC00961H
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