Issue 30, 2015
From the journal:

Chemical Communications

A continuous-flow mass biosensor for the real-time dynamic analysis of protease inhibition†

Yanyan Huang,a   Qundan Zhang,a   Guoquan Liua  and  Rui Zhao*a  

* Corresponding authors

a Beijing National Laboratory for Molecular Sciences, CAS Key Laboratory of Analytical Chemistry for Living Biosystems, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China
E-mail: zhaorui@iccas.ac.cn
Fax: +86-10-62559373
Tel: +86-10-62557910

Abstract

A flow injection analysis–quartz crystal microbalance (FIA–QCM) biosensor was developed for probing the dynamic interactions during protease inhibition. Being sensitive to conformation features of different proteases, this continuous-flow sensor has potential for structural–functional analysis and inhibitor selection.

Graphical abstract: A continuous-flow mass biosensor for the real-time dynamic analysis of protease inhibition

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Article information

DOI
https://doi.org/10.1039/C5CC00885A
Article type
Communication
Submitted
30 Jan 2015
Accepted
10 Mar 2015
First published
10 Mar 2015

Chem. Commun., 2015,51, 6601-6604

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A continuous-flow mass biosensor for the real-time dynamic analysis of protease inhibition

Y. Huang, Q. Zhang, G. Liu and R. Zhao, Chem. Commun., 2015, 51, 6601 DOI: 10.1039/C5CC00885A

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