Issue 32, 2015
From the journal:

Chemical Communications

i-Motifs are more stable than G-quadruplexes in a hydrated ionic liquid†

Hisae Tateishi-Karimata,a   Miki Nakano,a   Smritimoy Pramanik,a   Shigenori Tanakab  and  Naoki Sugimoto*ac  

* Corresponding authors

a Frontier Institute for Biomolecular Engineering Research (FIBER), Konan University, 7-1-20 Minatojima-minamachi, Kobe 650-0047, Japan

b Graduate School of System Informatics, Department of Computational Science, Kobe University, 1-1, Rokkodai, Nada-ku, Kobe, Japan

c Graduate School of Frontiers of Innovative Research in Science and Technology (FIRST), Konan University, 7-1-20 Minatojima-minamachi, Kobe 650-0047, Japan
E-mail: sugimoto@konan-u.ac.jp
Fax: +81-78-303-1495
Tel: +81-78-303-1457

Abstract

Thermodynamic analyses and molecular dynamics calculations demonstrated that i-motifs in a hydrated ionic liquid of choline dihydrogen phosphate (choline dhp) were more stable than G-quadruplexes due to choline ion binding to loop regions in the i-motifs. Interestingly, the i-motifs formed even at physiological pH in the choline dhp-containing solution.

Graphical abstract: i-Motifs are more stable than G-quadruplexes in a hydrated ionic liquid

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Article information

DOI
https://doi.org/10.1039/C5CC00666J
Article type
Communication
Submitted
30 Jan 2015
Accepted
23 Feb 2015
First published
25 Feb 2015

Chem. Commun., 2015,51, 6909-6912

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i-Motifs are more stable than G-quadruplexes in a hydrated ionic liquid

H. Tateishi-Karimata, M. Nakano, S. Pramanik, S. Tanaka and N. Sugimoto, Chem. Commun., 2015, 51, 6909 DOI: 10.1039/C5CC00666J

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