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Issue 30, 2015
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Direct oligonucleotide–photosensitizer conjugates for photochemical delivery of antisense oligonucleotides

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Abstract

Activation of photosensitizers in endosomes enables release of therapeutic macromolecules into the cytosol of the target cells for pharmacological actions. In this study, we demonstrate that direct conjugation of photosensitizers to oligonucleotides (ONs) allows spatial and temporal co-localization of the two modalities in the target cells, and thus leads to superior functional delivery of ONs. Further, light-activated delivery of an anticancer ON caused cancer cell killing via modulation of an oncogene and photodynamic therapy.

Graphical abstract: Direct oligonucleotide–photosensitizer conjugates for photochemical delivery of antisense oligonucleotides

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Publication details

The article was received on 21 Jan 2015, accepted on 10 Mar 2015 and first published on 10 Mar 2015


Article type: Communication
DOI: 10.1039/C5CC00573F
Author version available: Download Author version (PDF)
Citation: Chem. Commun., 2015,51, 6678-6680
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    Direct oligonucleotide–photosensitizer conjugates for photochemical delivery of antisense oligonucleotides

    A. Yuan, B. Laing, Y. Hu and X. Ming, Chem. Commun., 2015, 51, 6678
    DOI: 10.1039/C5CC00573F

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