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Issue 23, 2015
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Enzyme transformation to modulate the ligand–receptor interactions between small molecules

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Abstract

Enzymatic transformation is a fundamental process to control ligand–receptor interactions among proteins for signal transduction in cells. Here we report the first example of enzymatic transformation regulated ligand–receptor interactions of small molecules, in which enzymatic reaction changes the stoichiometry of the ligand–receptor binding from 1 : 1 to 1 : 2. We also show that this unique integration of enzymatic transformation and ligand–receptor interactions of small molecules is able to affect the fate of cells.

Graphical abstract: Enzyme transformation to modulate the ligand–receptor interactions between small molecules

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Publication details

The article was received on 28 Dec 2014, accepted on 12 Feb 2015 and first published on 12 Feb 2015


Article type: Communication
DOI: 10.1039/C4CC10374B
Citation: Chem. Commun., 2015,51, 4899-4901
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    Enzyme transformation to modulate the ligand–receptor interactions between small molecules

    J. Shi, X. Du, D. Yuan, R. Haburcak, D. Wu, N. Zhou and B. Xu, Chem. Commun., 2015, 51, 4899
    DOI: 10.1039/C4CC10374B

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