Issue 14, 2015
From the journal:

Chemical Communications

Rhodium(iii)-catalyzed C–H activation and intermolecular annulation with terminal alkynes: from indoles to carbazoles†

Jinlong Jia,‡ab   Jingjing Shi,‡a   Jie Zhou,ac   Xuelei Liu,a   Yanling Song,b   H. Eric Xu*ad  and  Wei Yi*a  

* Corresponding authors

a VARI/SIMM Center, Center for Structure and Function of Drug Targets, CAS-Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, P. R. China
E-mail: yiwei.simm@simm.ac.cn, eric.xu@simm.ac.cn
Fax: +86-21-20231000-1715
Tel: +86-21-20231000-1715

b College of Pharmaceutical and Biological Engineering, Shenyang University of Chemical Technology, Shenyang 110142, P. R. China

c School of Chemistry and Chemical Engineering, Sun Yat-sen University, Guangzhou 510275, P. R. China

d Laboratory of Structural Sciences, Program on Structural Biology and Drug Discovery, Van Andel Research Institute, Grand Rapids, Michigan 49503, USA

Abstract

Herein we disclose the first example of Rh(III)-catalyzed intermolecular annulation of indoles with terminal alkynes to give highly efficient one-pot access to privileged carbazoles. The mild reaction features moderate to good yields, exclusive regioselectivity, broad substrate scope, and excellent functional group tolerance.

Graphical abstract: Rhodium(iii)-catalyzed C–H activation and intermolecular annulation with terminal alkynes: from indoles to carbazoles

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Article information

DOI
https://doi.org/10.1039/C4CC09823D
Article type
Communication
Submitted
09 Dec 2014
Accepted
02 Jan 2015
First published
05 Jan 2015

Chem. Commun., 2015,51, 2925-2928

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Rhodium(III)-catalyzed C–H activation and intermolecular annulation with terminal alkynes: from indoles to carbazoles

J. Jia, J. Shi, J. Zhou, X. Liu, Y. Song, H. E. Xu and W. Yi, Chem. Commun., 2015, 51, 2925 DOI: 10.1039/C4CC09823D

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