Issue 16, 2015

Activatable photodynamic destruction of cancer cells by NIR dye/photosensitizer loaded liposomes

Abstract

The phototoxicity of Chlorin e6 (Ce6) for photodynamic therapy (PDT) was found to be effectively suppressed by indocyanine green (ICG), a near infrared (NIR) dye. Upon NIR laser irradiation at 808 nm, ICG in the liposomes containing ICG and Ce6 could be degraded, while the phototoxicity of Ce6 could be recovered. In addition, we demonstrate that this newly developed liposomal component can be successfully used for activatable PDT to destroy cancer cells in vitro.

Graphical abstract: Activatable photodynamic destruction of cancer cells by NIR dye/photosensitizer loaded liposomes

Supplementary files

Article information

Article type
Communication
Submitted
04 Dec 2014
Accepted
08 Jan 2015
First published
08 Jan 2015

Chem. Commun., 2015,51, 3340-3342

Author version available

Activatable photodynamic destruction of cancer cells by NIR dye/photosensitizer loaded liposomes

A. Yuan, X. Tang, X. Qiu, K. Jiang, J. Wu and Y. Hu, Chem. Commun., 2015, 51, 3340 DOI: 10.1039/C4CC09689D

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