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Issue 41, 2015
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On-chip monitoring of chemical syntheses in microdroplets via surface-enhanced Raman spectroscopy

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Abstract

Conducting organic syntheses in microfluidic chips allows studying and optimising chemical reactions at minimal time-scales and resource consumption. Herein, we describe a multi-channel microdroplet chip, which allows fast and directed dispensing of reactants into individual droplets in a segmented flow. This gives access to study the reaction progress in situ via surface-enhanced Raman spectroscopic monitoring of fast moving individual droplets. This opens up new avenues for high-throughput screening of organic reactions at the micro- and nano-scale.

Graphical abstract: On-chip monitoring of chemical syntheses in microdroplets via surface-enhanced Raman spectroscopy

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Publication details

The article was received on 01 Dec 2014, accepted on 12 Jan 2015 and first published on 12 Jan 2015


Article type: Communication
DOI: 10.1039/C4CC09595B
Citation: Chem. Commun., 2015,51, 8588-8591
  • Open access: Creative Commons BY license
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    On-chip monitoring of chemical syntheses in microdroplets via surface-enhanced Raman spectroscopy

    T.-A. Meier, R. J. Beulig, E. Klinge, M. Fuss, S. Ohla and D. Belder, Chem. Commun., 2015, 51, 8588
    DOI: 10.1039/C4CC09595B

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