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Issue 16, 2015
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N-Heterocyclic carbene-catalyzed enantioselective annulations: a dual activation strategy for a formal [4+2] addition for dihydrocoumarins

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Abstract

A highly efficient asymmetric formal [4+2] annulation for the synthesis of dihydrocoumarins has been developed via an in situ activated NHC catalysis. Both electrophilic and nucleophilic species are generated in situ simultaneously whereby acyl imidazoles facilitated rapid formation of an NHC-enolate intermediate to afford the [4+2] dihydrocoumarin adducts.

Graphical abstract: N-Heterocyclic carbene-catalyzed enantioselective annulations: a dual activation strategy for a formal [4+2] addition for dihydrocoumarins

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Publication details

The article was received on 01 Dec 2014, accepted on 15 Jan 2015 and first published on 19 Jan 2015


Article type: Communication
DOI: 10.1039/C4CC09590A
Citation: Chem. Commun., 2015,51, 3407-3410
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    N-Heterocyclic carbene-catalyzed enantioselective annulations: a dual activation strategy for a formal [4+2] addition for dihydrocoumarins

    A. Lee and K. A. Scheidt, Chem. Commun., 2015, 51, 3407
    DOI: 10.1039/C4CC09590A

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