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Issue 23, 2015
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Deuterated carbohydrate probes as ‘label-free’ substrates for probing nutrient uptake in mycobacteria by nuclear reaction analysis

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Abstract

Understanding and probing small molecule uptake in cells is challenging, requiring sterically large chemical labels, or radioactive isotopes. Here, the uptake of deuterated sugars by Mycobacterium smegmatis, a non-pathogenic model of Mycobacterium tuberculosis, has been investigated using ion-beam (nuclear reaction) analysis demonstrating a new technique for label-free nutrient acquisition measurement.

Graphical abstract: Deuterated carbohydrate probes as ‘label-free’ substrates for probing nutrient uptake in mycobacteria by nuclear reaction analysis

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Publication details

The article was received on 01 Dec 2014, accepted on 12 Feb 2015 and first published on 12 Feb 2015


Article type: Communication
DOI: 10.1039/C4CC09588J
Citation: Chem. Commun., 2015,51, 4838-4841
  • Open access: Creative Commons BY license
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    Deuterated carbohydrate probes as ‘label-free’ substrates for probing nutrient uptake in mycobacteria by nuclear reaction analysis

    R. Lowery, M. I. Gibson, R. L. Thompson and E. Fullam, Chem. Commun., 2015, 51, 4838
    DOI: 10.1039/C4CC09588J

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