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Issue 23, 2015
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Sequence-selective DNA binding with cell-permeable oligoguanidinium–peptide conjugates

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Abstract

Conjugation of a short peptide fragment from a bZIP protein to an oligoguanidinium tail results in a DNA-binding miniprotein that selectively interacts with composite sequences containing the peptide-binding site next to an A/T-rich tract. In addition to stabilizing the complex with the target DNA, the oligoguanidinium unit also endows the conjugate with cell internalization properties.

Graphical abstract: Sequence-selective DNA binding with cell-permeable oligoguanidinium–peptide conjugates

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Publication details

The article was received on 01 Dec 2014, accepted on 03 Feb 2015 and first published on 18 Feb 2015


Article type: Communication
DOI: 10.1039/C4CC09525A
Author version available: Download Author version (PDF)
Citation: Chem. Commun., 2015,51, 4811-4814
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    Sequence-selective DNA binding with cell-permeable oligoguanidinium–peptide conjugates

    J. Mosquera, M. I. Sánchez, J. Valero, J. D. Mendoza, M. E. Vázquez and J. L. Mascareñas, Chem. Commun., 2015, 51, 4811
    DOI: 10.1039/C4CC09525A

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