A novel type of dual pH-responsive supramolecular prodrug micelles based on host–guest interactions of water-soluble pillar[5]arene (WP5) and methyl viologen functioned doxorubicin (MV-DOX) was prepared. It was found that the prodrug micelles could be aggregated upon acidic condition, which led to enhanced accumulation and better therapy effect.
![Graphical abstract: Pillar[5]arene based supramolecular prodrug micelles with pH induced aggregate behavior for intracellular drug delivery](/en/Image/Get?imageInfo.ImageType=GA&imageInfo.ImageIdentifier.ManuscriptID=C4CC09274K&imageInfo.ImageIdentifier.Year=2015)
Y. Wang, J. Du, Y. Wang, Q. Jin and J. Ji, Chem. Commun., 2015, 51, 2999 DOI: 10.1039/C4CC09274K
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