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Issue 12, 2015
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Expanding the toolbox of organic chemists: directed evolution of P450 monooxygenases as catalysts in regio- and stereoselective oxidative hydroxylation

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Abstract

Cytochrome P450 enzymes (CYPs) have been used for more than six decades as catalysts for the CH-activating oxidative hydroxylation of organic compounds with formation of added-value products. However, it has not been possible to control regio- and stereoselectivity in a general manner, which is necessary for wide (industrial) applications. Especially directed evolution as a Darwinian approach to protein engineering has changed the situation for the better during the last 3–4 years leading to extensive progress, which is summarized and analysed in this Feature Article.

Graphical abstract: Expanding the toolbox of organic chemists: directed evolution of P450 monooxygenases as catalysts in regio- and stereoselective oxidative hydroxylation

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Publication details

The article was received on 18 Nov 2014, accepted on 28 Nov 2014 and first published on 08 Dec 2014


Article type: Feature Article
DOI: 10.1039/C4CC09218J
Author version available: Download Author version (PDF)
Citation: Chem. Commun., 2015,51, 2208-2224
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    Expanding the toolbox of organic chemists: directed evolution of P450 monooxygenases as catalysts in regio- and stereoselective oxidative hydroxylation

    G. Roiban and M. T. Reetz, Chem. Commun., 2015, 51, 2208
    DOI: 10.1039/C4CC09218J

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