Jump to main content
Jump to site search

Issue 37, 2015
Previous Article Next Article

Transcription of 4′-thioDNA templates to natural RNA in vitro and in mammalian cells

Author affiliations

Abstract

Synthetic chemically modified nucleic acids, which are compatible with DNA/RNA polymerases, have great potential as a genetic material for synthetic biological studies. A comprehensive analysis of the transcription of 4′-thioDNA templates to natural RNA is herein reported. The modifications of DNA with 2′-deoxy-4′-thionucleosides, so-called 4′-thioDNA, were found to act as templates for transcription with RNA polymerases both in vitro and in mammalian cells.

Graphical abstract: Transcription of 4′-thioDNA templates to natural RNA in vitro and in mammalian cells

Back to tab navigation

Supplementary files

Publication details

The article was received on 06 Nov 2014, accepted on 09 Mar 2015 and first published on 10 Mar 2015


Article type: Communication
DOI: 10.1039/C4CC08862J
Citation: Chem. Commun., 2015,51, 7887-7890
  •   Request permissions

    Transcription of 4′-thioDNA templates to natural RNA in vitro and in mammalian cells

    H. Maruyama, K. Furukawa, H. Kamiya, N. Minakawa and A. Matsuda, Chem. Commun., 2015, 51, 7887
    DOI: 10.1039/C4CC08862J

Search articles by author

Spotlight

Advertisements