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Issue 1, 2015
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Pyridynes and indolynes as building blocks for functionalized heterocycles and natural products

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Abstract

Heterocyclic arynes, or hetarynes, have been studied for over 100 years. However, challenges associated with observing these reactive species, as well as developing synthetically useful methods for their generation and trapping, have limited their use. This review provides a brief historical perspective on the field of hetarynes, in addition to a discussion of pyridyne and indolyne methodologies. Moreover, this review highlights the use of pyridynes, indolynes, and related strained intermediates in natural product synthesis.

Graphical abstract: Pyridynes and indolynes as building blocks for functionalized heterocycles and natural products

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Publication details

The article was received on 16 Aug 2014, accepted on 04 Sep 2014 and first published on 05 Sep 2014


Article type: Feature Article
DOI: 10.1039/C4CC06445C
Citation: Chem. Commun., 2015,51, 34-45
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    Pyridynes and indolynes as building blocks for functionalized heterocycles and natural products

    A. E. Goetz, T. K. Shah and N. K. Garg, Chem. Commun., 2015, 51, 34
    DOI: 10.1039/C4CC06445C

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