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Issue 6, 2015
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Porphyrin derivatives as potent and selective blockers of neuronal Kv1 channels

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Abstract

Selective inhibitors of voltage-activated K+ channels are needed for the treatment of multiple sclerosis. In this work it was discovered that porphyrins bearing 2–4 carbon alkyl ammonium side chains predominantly blocked the Kv1.1 current whilst Kv1.2 was susceptible to a porphyrin bearing polyamine side chains.

Graphical abstract: Porphyrin derivatives as potent and selective blockers of neuronal Kv1 channels

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Publication details

The article was received on 21 Jul 2014, accepted on 17 Nov 2014 and first published on 18 Nov 2014


Article type: Communication
DOI: 10.1039/C4CC05639F
Author version available: Download Author version (PDF)
Citation: Chem. Commun., 2015,51, 1066-1069
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    Porphyrin derivatives as potent and selective blockers of neuronal Kv1 channels

    D. Daly, A. Al-Sabi, G. K. Kinsella, K. Nolan and J. O. Dolly, Chem. Commun., 2015, 51, 1066
    DOI: 10.1039/C4CC05639F

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