Issue 5, 2015

Nanoparticles for inhibition of in vitro tumour angiogenesis: synergistic actions of ligand function and laser irradiation

Abstract

Careful design of nanoparticles plays a crucial role in their biomedical applications. It not only defines the stability of nanoparticles in a biological medium but also programs their biological functionality and specific interactions with cells. Here, an inorganic nanoparticulate system engineered to have a dual role as anti-angiogenic and hyperthermic agent is presented. The inorganic rod-shaped core is designed to strongly absorb near-infrared laser irradiation through the surface plasmon resonance and convert it into localized heat, while a peptide coating acts as an anti-angiogenic drug, altogether inhibiting vascular growth. The synergistic dual action provides an improved inhibition of the in vitro tumour angiogenesis, offering new possibilities for the development of nano-engineered anti-angiogenic drugs for therapies.

Graphical abstract: Nanoparticles for inhibition of in vitro tumour angiogenesis: synergistic actions of ligand function and laser irradiation

Supplementary files

Article information

Article type
Paper
Submitted
18 Feb 2015
Accepted
13 Mar 2015
First published
23 Mar 2015

Biomater. Sci., 2015,3, 733-741

Nanoparticles for inhibition of in vitro tumour angiogenesis: synergistic actions of ligand function and laser irradiation

D. Bartczak, O. L. Muskens, S. Nitti, T. M. Millar and A. G. Kanaras, Biomater. Sci., 2015, 3, 733 DOI: 10.1039/C5BM00053J

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