A biopolymeric nano-receptor for sensitive and selective recognition of albendazole

Abstract

A molecularly imprinted electrochemical sensor was developed for albendazole (ABZ) based on chitosan nanoparticles. A polymeric film was formed on the surface of a gold electrode by electrodepositing nanoparticles of biopolymer chitosan in the presence of an ABZ template by cyclic voltammetry (CV). Various parameters were optimized for controlling the performance of the molecularly imprinted polymer (MIP) modified sensor. The prepared MIP sensor was specific towards ABZ and the recognition was analyzed by differential pulse voltammetry (DPV) to verify the changes in currents. Under optimal conditions, the response of the MIP sensor to ABZ was linearly proportional to its concentration with a limit of detection (LOD) of 0.119 μg mL⁻¹. Hence, a sensitive and selective electrochemical sensor in an ecofriendly biopolymer-derived nanoconfiguration for ABZ has been reported here via an imprinting approach.