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Issue 24, 2015
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Nanoparticle-assisted laser desorption/ionization using sinapic acid-modified iron oxide nanoparticles for mass spectrometry analysis

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Abstract

Iron oxide-based nanoparticles (NP) were covalently modified with sinapic acid (SA) through a condensation reaction to assist the ionization of both large and small molecules. The morphology of SA-modified NPs (SA-NP) was characterized by transmission electron microscopy (TEM), and the modification of the NP surface with SA was confirmed using ultraviolet (UV) and infrared (IR) spectroscopy. The number of SA molecules was estimated to be 6 per NP. SA-NP-assisted laser desorption/ionization was carried out on small molecules, such as pesticides and plant hormones, and large molecules, such as peptides and proteins. A peptide fragment from degraded proteins was detected more efficiently compared with conventional methods.

Graphical abstract: Nanoparticle-assisted laser desorption/ionization using sinapic acid-modified iron oxide nanoparticles for mass spectrometry analysis

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Publication details

The article was received on 08 Oct 2015, accepted on 19 Oct 2015 and first published on 20 Oct 2015


Article type: Paper
DOI: 10.1039/C5AN02081F
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Citation: Analyst, 2015,140, 8134-8137
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    Nanoparticle-assisted laser desorption/ionization using sinapic acid-modified iron oxide nanoparticles for mass spectrometry analysis

    H. Komori, R. Hashizaki, I. Osaka, T. Hibi, H. Katano and S. Taira, Analyst, 2015, 140, 8134
    DOI: 10.1039/C5AN02081F

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