Issue 13, 2015
From the journal:

Dalton Transactions

A hypoxia efficient imidazole-based Ru(ii) arene anticancer agent resistant to deactivation by glutathione†

Kallol Purkait,‡a   Subhendu Karmakar,‡a   Sudipta Bhattacharyya,a   Saptarshi Chatterjee,a   Suman Kr Deya  and  Arindam Mukherjee*a  

* Corresponding authors

a Department of Chemical Sciences, Indian Institute of Science Education and Research Kolkata, Mohanpur campus, Mohanpur-741246, India
E-mail: a.mukherjee@iiserkol.ac.in
Fax: +91-33-25873020

Abstract

A slow hydrolyzing imidazole-based RuII-arene complex [(L)RuII(η6-p-cym)(Cl)](PF6) (1) with excellent stability in the extracellular chloride concentration shows better activity under hypoxia and strong resistance to glutathione (GSH) in vitro under hypoxic conditions. 1 arrests the cell cycle in sub G1 and G2/M phases and leads to apoptosis.

Graphical abstract: A hypoxia efficient imidazole-based Ru(ii) arene anticancer agent resistant to deactivation by glutathione

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Article information

DOI
https://doi.org/10.1039/C4DT03983A
Article type
Communication
Submitted
24 Dec 2014
Accepted
15 Feb 2015
First published
18 Feb 2015
This article is Open Access
Creative Commons BY-NC license

Dalton Trans., 2015,44, 5969-5973

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A hypoxia efficient imidazole-based Ru(II) arene anticancer agent resistant to deactivation by glutathione

K. Purkait, S. Karmakar, S. Bhattacharyya, S. Chatterjee, S. K. Dey and A. Mukherjee, Dalton Trans., 2015, 44, 5969 DOI: 10.1039/C4DT03983A

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