Using light irradiation as a trigger, large-scale structural reconfiguration of DNA nanostructures is demonstrated. We incorporated photo-cleavable spacers at strategic locations within the short oligonucleotide strands connecting adjacent helices within a DNA origami sphere, and then used light to transform the sphere into two tethered hemispheres.
R. E. Kohman and X. Han, Chem. Commun., 2015, 51, 5747 DOI: 10.1039/C5CC00082C
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