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Issue 19, 2016
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Alginate microgels created by selective coalescence between core drops paired with an ultrathin shell

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Abstract

We report a highly biocompatible and practical protocol to create alginate microgels for bioactive encapsulation. Double-emulsion drops composed of dual cores enclosed by an ultrathin shell are prepared in a capillary microfluidic device, which exhibit selective coalescence between the cores. When the cores are laden with alginate precursors and divalent ions, respectively, coalescence leads to the formation of alginate microgels in the fused core of double-emulsion drops. The microgel can be rapidly released into a continuous water phase by rupturing the liquid shell. This method neither involves any toxic chemical cues for gelation nor long-term exposure to oil, thereby providing highly biocompatible encapsulation.

Graphical abstract: Alginate microgels created by selective coalescence between core drops paired with an ultrathin shell

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Publication details

The article was received on 04 Mar 2016, accepted on 05 Apr 2016 and first published on 05 Apr 2016


Article type: Paper
DOI: 10.1039/C6TB00580B
Citation: J. Mater. Chem. B, 2016,4, 3232-3238
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    Alginate microgels created by selective coalescence between core drops paired with an ultrathin shell

    T. Y. Lee, R. Praveenkumar, Y. Oh, K. Lee and S. Kim, J. Mater. Chem. B, 2016, 4, 3232
    DOI: 10.1039/C6TB00580B

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