Jump to main content
Jump to site search

Issue 47, 2014
Previous Article Next Article

Water-soluble photoluminescent D-mannose and L-alanine functionalized silicon nanocrystals and their application to cancer cell imaging

Author affiliations

Abstract

Herein, we report the straightforward synthesis, photoluminescent properties, and cell imaging studies of D-mannose and L-alanine functionalized silicon nanocrystals (SiNCs). Tailoring nanocrystal surface functionalization is essential to interfacing SiNCs with their environment and rendering them stable – surface modification also offers the opportunity to target specific cell types for imaging. A simple and versatile surface modification procedure was developed to tether biomolecules onto the SiNC surfaces and render them water-soluble. The presented approach is precious metal-catalyst free, straightforward, and provides carbohydrate and amino acid functionalized SiNCs. The functionalized SiNCs have been investigated by fluorescence microscopy and our results indicate that they can be internalized by MCF-7 human breast cancer cells as shown in the cell imaging studies. The obtained SiNCs were characterized using FTIR, XPS, PL, and TEM.

Graphical abstract: Water-soluble photoluminescent d-mannose and l-alanine functionalized silicon nanocrystals and their application to cancer cell imaging

Back to tab navigation

Supplementary files

Publication details

The article was received on 15 Jul 2014, accepted on 15 Oct 2014 and first published on 22 Oct 2014


Article type: Paper
DOI: 10.1039/C4TB01161A
Citation: J. Mater. Chem. B, 2014,2, 8427-8433
  • Open access: Creative Commons BY license
  •   Request permissions

    Water-soluble photoluminescent D-mannose and L-alanine functionalized silicon nanocrystals and their application to cancer cell imaging

    Y. Zhai, M. Dasog, R. B. Snitynsky, T. K. Purkait, M. Aghajamali, A. H. Hahn, C. B. Sturdy, T. L. Lowary and J. G. C. Veinot, J. Mater. Chem. B, 2014, 2, 8427
    DOI: 10.1039/C4TB01161A

    This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. Material from this article can be used in other publications provided that the correct acknowledgement is given with the reproduced material.

    Reproduced material should be attributed as follows:

    • For reproduction of material from NJC:
      [Original citation] - Published by The Royal Society of Chemistry (RSC) on behalf of the Centre National de la Recherche Scientifique (CNRS) and the RSC.
    • For reproduction of material from PCCP:
      [Original citation] - Published by the PCCP Owner Societies.
    • For reproduction of material from PPS:
      [Original citation] - Published by The Royal Society of Chemistry (RSC) on behalf of the European Society for Photobiology, the European Photochemistry Association, and RSC.
    • For reproduction of material from all other RSC journals:
      [Original citation] - Published by The Royal Society of Chemistry.

    Information about reproducing material from RSC articles with different licences is available on our Permission Requests page.

Search articles by author

Spotlight

Advertisements