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Issue 28, 2014
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NIR excitation of upconversion nanohybrids containing a surface grafted Bodipy induces oxygen-mediated cancer cell death

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Abstract

We report the preparation of water-dispersible, ca. 30 nm-sized nanohybrids containing NaYF4:Er3+, Yb3+ up-conversion nanoparticles (UCNPs), capped with a polyethylene glycol (PEG) derivative and highly loaded with a singlet oxygen photosensitizer, specifically a diiodo-substituted Bodipy (IBDP). The photosensitizer, bearing a carboxylic group, was anchored to the UCNP surface and, at the same time, embedded in the PEG capping; the combined action of the UCNP surface and PEG facilitated the loading for an effective energy transfer and, additionally, avoided photosensitizer leaching from the nanohybrid (UCNP–IBDP@PEG). The effectiveness of the nanohybrids in generating singlet oxygen after near-infrared (NIR) excitation (975 nm) with a continuous wavelength (CW) laser was evidenced by using a probe molecule. In vitro assays demonstrated that the UCNP–IBDP@PEG nanohybrid was taken up by the SH-SY5Y human neuroblastoma-derived cells showing low cytotoxicity. Moreover, ca. 50% cancer cell death was observed after NIR irradiation (45 min, 239 mW).

Graphical abstract: NIR excitation of upconversion nanohybrids containing a surface grafted Bodipy induces oxygen-mediated cancer cell death

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Publication details

The article was received on 28 Feb 2014, accepted on 06 May 2014 and first published on 12 May 2014


Article type: Paper
DOI: 10.1039/C4TB00340C
Author version available: Download Author version (PDF)
Citation: J. Mater. Chem. B, 2014,2, 4554-4563
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    NIR excitation of upconversion nanohybrids containing a surface grafted Bodipy induces oxygen-mediated cancer cell death

    M. González-Béjar, M. Liras, L. Francés-Soriano, V. Voliani, V. Herranz-Pérez, M. Duran-Moreno, J. M. Garcia-Verdugo, E. I. Alarcon, J. C. Scaiano and J. Pérez-Prieto, J. Mater. Chem. B, 2014, 2, 4554
    DOI: 10.1039/C4TB00340C

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