Jump to main content
Jump to site search

Issue 20, 2014
Previous Article Next Article

PEG–poly(amino acid)s-encapsulated tanshinone IIA as potential therapeutics for the treatment of hepatoma

Author affiliations

Abstract

Tanshinone IIA is a potent anti-tumor agent; however, its therapeutic applications have been hindered by its intrinsic poor solubility and short half-life. Herein we report the design and synthesis of amphiphilic PEG–poly(amino acid)s (PPAAs), which were used as a nanocarrier to encapsulate tanshinone IIA. PPAA-encapsulated tanshinone IIA formed defined nanoparticles and effectively arrested the growth of the hepatoma tumor in MHCC97-H hepatoma-bearing mice, which has therefore significantly increased their survival time. Moreover, these tanshinone-loaded nanoparticles are also capable of suppressing hepatic tumor cell migration and metastasis. In all cases, they significantly improve efficacy compared to tanshinone alone. Our results show that tanshinone IIA encapsulated by PPAAs is a potential novel nanomedicine for the treatment of hepatoma. Furthermore, this use is only a proof of concept, and PPAAs can be used as a potential drug delivery system for a much broader array of hydrophobic drugs.

Graphical abstract: PEG–poly(amino acid)s-encapsulated tanshinone IIA as potential therapeutics for the treatment of hepatoma

Back to tab navigation

Publication details

The article was received on 08 Jan 2014, accepted on 07 Mar 2014 and first published on 07 Mar 2014


Article type: Paper
DOI: 10.1039/C4TB00041B
Author version
available:
Download author version (PDF)
Citation: J. Mater. Chem. B, 2014,2, 3115-3122
  •   Request permissions

    PEG–poly(amino acid)s-encapsulated tanshinone IIA as potential therapeutics for the treatment of hepatoma

    Y. Wang, F. Costanza, H. Wu, D. Song, J. Cai and Q. Li, J. Mater. Chem. B, 2014, 2, 3115
    DOI: 10.1039/C4TB00041B

Search articles by author

Spotlight

Advertisements