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Issue 18, 2014
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An intercompartmental enzymatic cascade reaction in channel-equipped polymersome-in-polymersome architectures

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Abstract

Compartmentalization, as a design principle, is a prerequisite for the functioning of eukaryotic cells. Although cell mimics in the form of single vesicular compartments such as liposomes or polymersomes have been tremendously successful, investigations of the corresponding higher-order architectures, in particular bilayer-based multicompartment vesicles, have only recently gained attention. We hereby demonstrate a multicompartment cell-mimetic nanocontainer, built-up from fully synthetic membranes, which features an inner compartment equipped with a channel protein and a semi-permeable outer compartment that allows passive diffusion of small molecules. The functionality of this multicompartment architecture is demonstrated by a cascade reaction between enzymes that are segregated in separate compartments. The unique architecture of polymersomes, which combines stability with a cell-membrane-mimetic environment, and their assembly into higher-order architectures could serve as a design principle for new generation drug-delivery vehicles, biosensors, and protocell models.

Graphical abstract: An intercompartmental enzymatic cascade reaction in channel-equipped polymersome-in-polymersome architectures

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Publication details

The article was received on 27 Dec 2013, accepted on 27 Feb 2014 and first published on 27 Feb 2014


Article type: Paper
DOI: 10.1039/C3TB21849J
Author version available: Download Author version (PDF)
Citation: J. Mater. Chem. B, 2014,2, 2733-2737
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    An intercompartmental enzymatic cascade reaction in channel-equipped polymersome-in-polymersome architectures

    W. Siti, H. M. de Hoog, O. Fischer, W. Y. Shan, N. Tomczak, M. Nallani and B. Liedberg, J. Mater. Chem. B, 2014, 2, 2733
    DOI: 10.1039/C3TB21849J

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