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Issue 23, 2014
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Influence of sorbitol on protein crowding in solution and freeze-concentrated phases

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Abstract

Small-angle neutron scattering was employed to study protein crowding under freezing conditions that mimic those used in pharmaceutical processing. The results demonstrate that, although there is an increase in heterogeneity as the temperature is reduced, sorbitol reduces protein crowding in both solution and freeze-concentrated phases, thus protecting the protein from forming oligomers or irreversible aggregates.

Graphical abstract: Influence of sorbitol on protein crowding in solution and freeze-concentrated phases

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Publication details

The article was received on 19 Mar 2014, accepted on 31 Mar 2014 and first published on 02 Apr 2014


Article type: Communication
DOI: 10.1039/C4SM00600C
Author version available: Download Author version (PDF)
Citation: Soft Matter, 2014,10, 4056-4060
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    Influence of sorbitol on protein crowding in solution and freeze-concentrated phases

    S. Khodadadi, N. J. Clark, A. McAuley, V. Cristiglio, J. E. Curtis, E. Y. Shalaev and S. Krueger, Soft Matter, 2014, 10, 4056
    DOI: 10.1039/C4SM00600C

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