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Issue 1, 2015
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In vivo visible light-triggered drug release from an implanted depot

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Abstract

Controlling chemistry in space and time has offered scientists and engineers powerful tools for research and technology. For example, on-demand photo-triggered activation of neurotransmitters has revolutionized neuroscience. Non-invasive control of the availability of bioactive molecules in living organisms will undoubtedly lead to major advances; however, this requires the development of photosystems that efficiently respond to regions of the electromagnetic spectrum that innocuously penetrate tissue. To this end, we have developed a polymer that photochemically degrades upon absorption of one photon of visible light and demonstrated its potential for medical applications. Particles formulated from this polymer release molecular cargo in vitro and in vivo upon irradiation with blue visible light through a photoexpansile swelling mechanism.

Graphical abstract: In vivo visible light-triggered drug release from an implanted depot

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Publication details

The article was received on 29 Aug 2014, accepted on 04 Oct 2014 and first published on 06 Oct 2014


Article type: Edge Article
DOI: 10.1039/C4SC02651A
Citation: Chem. Sci., 2015,6, 335-341
  • Open access: Creative Commons BY-NC license
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    In vivo visible light-triggered drug release from an implanted depot

    C. Carling, M. L. Viger, V. A. Nguyen Huu, A. V. Garcia and A. Almutairi, Chem. Sci., 2015, 6, 335
    DOI: 10.1039/C4SC02651A

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